Purification and Properties of Hydroxyindole-O-methyl Transferase
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چکیده
منابع مشابه
Purification and properties of hydroxyindole-O-methyl transferase.
The demonstration of the hormone mclatonin (N-acetyl-Bmethoxytryptamine) in bovine pineal gland (1) prompted a study of the enzymes involved in its formation and metabolism. In preliminary studies (2, 3) we described an enzyme, hydroxyindole-O-methyl transferase, in the pineal gland of cows, that catalyzes the 0-methylation of N-acetyl-serotonin to melatonin. This paper describes the purificati...
متن کاملPurification and Properties of Hydroxyindole- O-meth-vl Transferase
The demonstration of the hormone mclatonin (N-acetyl-Bmethoxytryptamine) in bovine pineal gland (1) prompted a study of the enzymes involved in its formation and metabolism. In preliminary studies (2, 3) we described an enzyme, hydroxyindole-O-methyl transferase, in the pineal gland of cows, that catalyzes the 0-methylation of N-acetyl-serotonin to melatonin. This paper describes the purificati...
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The methylation of norepinephrine to epinephrine was first demonstrated by Biilbring with the use of minced adrenal gland and adenosine triphosphate (2). Soon after, Keller, Boissonnas, and du Vigneaud (3) showed that the methyl group of methionine is incorporated into the epinephrine of the adrenal gland in the intact animal. Subsequently, S-adenosylmethionine was shown to be the methyl donor ...
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investigation (Wurtman et a!., 1968; Reiter and Sorrentino, 1970). Among several indolie compounds produced by the pineal is melatonin, a presumptive hormone which exhibits anti-gonadotropic activity in the rat and other mammals. Early work demonstrated that melatonin reversed the persistent estrus induced in rats by continuous lighting (Wurtman et al., 1964); injections of the indole decreased...
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Catechol-O-methyl transferase (COMT) is an enzyme involved in the degradation of dopamine. The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT enzyme activity. It is particularely important in prefrontal cortex, since COMT activity is the most important regulator of the prefrontal dopamine function. Gi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1961
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)64458-8